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- Title
Iron-Catalyzed Intermolecular 1,2-Difunctionalization of Styrenes and Conjugated Alkenes with Silanes and Nucleophiles.
- Authors
Yang, Yuan; Song, Ren‐Jie; Ouyang, Xuan‐Hui; Wang, Cheng‐Yong; Li, Jin‐Heng; Luo, Shenglian
- Abstract
The first iron-catalyzed 1,2-difunctionalization of styrenes and conjugated alkenes with silanes and either N or C, using an oxidative radical strategy, is described. Employing FeCl2 and di- tert-butyl peroxide allows divergent alkene 1,2-difunctionalizations, including 1,2-aminosilylation, 1,2-arylsilylation, and 1,2-alkylsilylation, which rely on a wide range of nucleophiles, namely, amines, amides, indoles, pyrroles, and 1,3-dicarbonyls, thus providing a powerful platform for producing diverse silicon-containing alkanes.
- Subjects
IRON catalysts; FUNCTIONAL groups; STYRENE; ALKENES; SILANE compounds; NUCLEOPHILES; RADICALS (Chemistry)
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 27, p8024
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201702349