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- Title
Selective Reductive Removal of Ester and Amide Groups from Arenes and Heteroarenes through Nickel-Catalyzed C−O and C−N Bond Activation.
- Authors
Yue, Huifeng; Guo, Lin; Lee, Shao ‐ Chi; Liu, Xiangqian; Rueping, Magnus
- Abstract
An inexpensive nickel(II) catalyst and a hydrosilane were used for the efficient reductive defunctionalization of aryl and heteroaryl esters through a decarbonylative pathway. This versatile method could be used for the removal of ester and amide functional groups from various organic molecules. Moreover, a scale-up experiment and a synthetic application based on the use of a removable carboxylic acid directing group highlight the usefulness of this reaction.
- Subjects
NICKEL catalysts; CATALYTIC reduction; ESTERS; AMIDES; SCISSION (Chemistry); HETEROARENES; CARBOXYLIC acids
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 14, p4030
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201612624