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- Title
Copper(II)-Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers.
- Authors
Vegas, Verónica G.; Lorca, Romina; Latorre, Ana; Hassanein, Khaled; Gómez ‐ García, Carlos J.; Castillo, Oscar; Somoza, Álvaro; Zamora, Félix; Amo ‐ Ochoa, Pilar
- Abstract
The direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4′-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150-185 nm; diameter ca. 15-60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines-despite the copper(II) content-and can be used as nanocarriers of oligonucleotides. These results suggest the potential of these types of nanostructures in several biological applications.
- Subjects
NANORIBBONS; OLIGONUCLEOTIDES; ACETIC acid; SUPRAMOLECULAR chemistry; CELL lines; MOLECULAR structure
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 4, p1007
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201609031