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- Title
Clotting Activity of Polyphosphate-Functionalized Silica Nanoparticles.
- Authors
Kudela, Damien; Smith, Stephanie A.; May ‐ Masnou, Anna; Braun, Gary B.; Pallaoro, Alessia; Nguyen, Chi K.; Chuong, Tracy T.; Nownes, Sara; Allen, Riley; Parker, Nicholas R.; Rashidi, Hooman H.; Morrissey, James H.; Stucky, Galen D.
- Abstract
We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.
- Subjects
BLOOD coagulation; SILICA nanoparticles; THROMBIN; HEMOSTASIS; FIBRIN; POLYPHOSPHATES
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 13, p4090
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201409639