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- Title
Surface Functionalization of Micro/Nanostructured Titanium with Bioactive Ions to Regulate the Behaviors of Murine Osteoblasts.
- Authors
Wang, Guisen; Wan, Yi; Ren, Bing; Wang, Teng; Liu, Zhanqiang
- Abstract
Surface topography and chemical composition are centrally important in current implants for enhancing cellular responses. To investigate the synergistic effect of micro/nanostructure and bioactive ions on the spreading, proliferation, and differentiation of murine osteoblasts, the micro/nanostructured titanium surface containing bioactive ions (Zn2+ and Sr2+) was fabricated via sandblasting, acid etching, alkali-heat treatment, and ion exchange. Compared to polished titanium substrates, micro/nanostructured titanium substrates displayed the enhanced roughness and hydrophilicity. And surface functionalization of micro/nanostructured using Zn2+/Sr2+ ions exhibited the sustained release for a period of time. Meanwhile, cell experiments indicated that the Zn/Sr loaded micro/nanostructured titanium surfaces had a great potential to promote cell spreading, proliferation, and differentiation. This study provides a more promising method to design the surface of titanium implants for enhancing osseointegration.
- Subjects
OSTEOBLASTS; SAND blasting; OSSEOINTEGRATION
- Publication
Advanced Engineering Materials, 2017, Vol 19, Issue 11, pn/a
- ISSN
1438-1656
- Publication type
Article
- DOI
10.1002/adem.201700299