We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats.
- Authors
Breczko, Wioleta Jadwiga; Bubak, Joanna; Miszczak, Marta
- Abstract
Simple Summary: Cancer of the lymphatic system is a prevalent disease in dogs and cats, with older pets being the most affected group. However, it is crucial to recognize that animals of any age can develop this condition. Intestinal lymphoma, a type of neoplasm, arises when lymphocytes—white blood cells—become cancerous and proliferate uncontrollably. Recent research suggests that the microbiota, the community of bacteria and other microorganisms in the intestines, may play a role in the development of various diseases, including intestinal lymphoma. A healthy microbiota supports the immune system and prevents harmful cellular changes. In contrast, an imbalance in these microorganisms, potentially caused by poor diet, antibiotic use, or illness, can lead to inflammation and increase the risk of cancer. Recent advancements have significantly enhanced our understanding of the crucial role animal microbiomes play in veterinary medicine. Their importance in the complex intestinal environment spans immune modulation, metabolic homeostasis, and the pathogenesis of chronic diseases. Dysbiosis, a microbial imbalance, can lead to a range of diseases affecting both individual organs and the entire organism. Microbial disruption triggers inflammatory responses in the intestinal mucosa and disturbs immune homeostasis, increasing susceptibility to toxins and their metabolites. These dynamics contribute to the development of intestinal lymphoma, necessitating rigorous investigation into the role of microbiota in tumorigenesis. The principles explored in this study extend beyond veterinary medicine to encompass broader human health concerns. There are remarkable parallels between the subtypes of lymphoproliferative disorders in animals and humans, particularly Hodgkin's lymphoma and non-Hodgkin's lymphoma. Understanding the etiology of a cancer of the lymphatic system formation is critical for developing both preventive strategies and therapeutic interventions, with the potential to significantly improve patient outcomes. The aim of this study is to discuss the optimal composition of the microbiome in dogs and cats and the potential alterations in the microbiota during the development of intestinal lesions, particularly intestinal lymphoma. Molecular and cellular analyses are also incorporated to detect inflammatory changes and carcinogenesis. A review of the literature on the connections between the gut microbiome and the development of lymphomas in dogs and cats is presented, along with potential diagnostic approaches for these cancers.
- Subjects
ANTIBIOTICS; LEUCOCYTES; GUT microbiome; LYMPHOMAS; DOGS; CATS; INTESTINAL tumors; PATHOGENESIS; INFLAMMATION; CARCINOGENESIS; DIET
- Publication
Cancers, 2024, Vol 16, Issue 12, p2255
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16122255