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- Title
Predictability of k<sub>L</sub> a in stirred tank reactors under multiple operating conditions using an Euler-Lagrange approach.
- Authors
Wutz, Johannes; Lapin, Alexey; Siebler, Flora; Schäfer, Jan Erik; Wucherpfennig, Thomas; Berger, Martina; Takors, Ralf
- Abstract
In industrial cell culture engineering, the production process consists of a multiscale seed train from lab scale to large scale. The oxygen demand of the cells has to be satisfied in all scales. Computational fluid dynamics (CFD) simulations can provide a tool to predict the mass transfer between the gas phase and the liquid phase. In this work, CFD was applied using an Euler-Lagrange approach for the prediction of the mass transfer coefficient (
- Subjects
COMPUTATIONAL fluid dynamics; LAGRANGE equations; BIOREACTORS; EULER-Lagrange equations; GAS phase reactions
- Publication
Engineering in Life Sciences, 2016, Vol 16, Issue 7, p633
- ISSN
1618-0240
- Publication type
Article
- DOI
10.1002/elsc.201500135