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- Title
Histologic comparison of vibrating guidewire with conventional guidewire technique in an experimental coronary in vivo model.
- Authors
Katsouras, Christos S.; Michalis, Lampros K.; Malamou-Mitsi, Vassiliki D.; Niokou, Demetra; Giogiakas, Vassilios; Nikas, Dimitrios; Massouras, Gerasimos; Dallas, Pavios; Tsetis, Dimitrios K.; Sideris, Dimitris A.; Rees, Michael R.; Dallas, Pavlos
- Abstract
<bold>Purpose: </bold>To compare the damage caused by vibrating guidewire manipulation and conventional guidewire manipulation of soft coronary wires in normal sheep coronary arteries.<bold>Methods: </bold>Using an intact sheep model the two methods of passing a coronary guidewire down a normal coronary artery under fluoroscopic screening control were studied. The resulting arterial damage caused by the two techniques was studied histologically. The severity of damage was scored from 1 (no damage) to 4 (severe damage) and expressed as: (a) percentage of damaged sections, (b) mean damage score per section and (c) percentage of sections suffering the most severe degree of damage (scores 3 and 4).<bold>Results: </bold>One hundred and sixty-eight sections were studied. The percentage of damaged sections was lower in the vibrating guidewire group (p = 0.004). The mean damage score and the percentage of sections with a damage score of 3 or 4 were smaller in the vibrating guidewire group than in the conventional guidewire manipulation group (p = 0.001 and p = 0.009, respectively).<bold>Conclusions: </bold>Both methods of guidewire manipulation cause identifiable vascular damage. The extent and severity of damage appear greater when the guidewire is manipulated manually.
- Subjects
HEART blood-vessels; CORONARY arteries; ANEURYSMS; VASCULAR diseases; MEDICAL screening; HISTOPATHOLOGY; CORONARY artery injuries; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SHEEP; TRANSLUMINAL angioplasty; VIBRATION (Mechanics); PRODUCT design; EVALUATION research
- Publication
CardioVascular & Interventional Radiology, 2003, Vol 26, Issue 5, p454
- ISSN
0174-1551
- Publication type
journal article
- DOI
10.1007/s00270-003-2667-0