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- Title
Impact of Blood Pressure on Allograft Function and Survival in Kidney Transplant Recipients.
- Authors
Hyo Jeong Kim; Kyung Won Kim; Young Su Joo; Junghwa Ryu; Hee-Yeon Jung; Kyung Hwan Jeong; Myung-Gyu Kim; Man Ki Ju; Seungyeup Han; Jong Soo Lee; Kyung Pyo Kang; Han Ro; Kyo Won Lee; Kyu Ha Huh; Myoung Soo Kim; Beom Seok Kim; Jaeseok Yang
- Abstract
The optimal target blood pressure for kidney transplant (KT) patients remains unclear. We included 808 KT patients from the KNOW-KT as a discovery set, and 1,294 KT patients from the KOTRY as a validation set. The main exposures were baseline systolic blood pressure (SBP) at 1 year after KT and time-varying SBP. Patients were classified into five groups: SBP <110; 110-119; 120-129; 130-139; and =140 mmHg. SBP trajectories were classified into decreasing, stable, and increasing groups. Primary outcome was composite kidney outcome of =50% decrease in eGFR or death-censored graft loss. Compared with the 110-119 mmHg group, both the lowest (adjusted hazard ratio [aHR], 2.43) and the highest SBP (aHR, 2.25) were associated with a higher risk of composite kidney outcome. In time-varying model, also the lowest (aHR, 3.02) and the highest SBP (aHR, 3.60) were associated with a higher risk. In the trajectory model, an increasing SBP trajectory was associated with a higher risk than a stable SBP trajectory (aHR, 2.26). This associations were consistent in the validation set. In conclusion, SBP =140 mmHg and an increasing SBP trajectory were associated with a higher risk of allograft dysfunction and failure in KT patients.
- Subjects
SYSTOLIC blood pressure; KIDNEY transplantation; BLOOD pressure; GRAFT survival; HOMOGRAFTS
- Publication
Transplant International, 2024, p1
- ISSN
0934-0874
- Publication type
Article
- DOI
10.3389/ti.2024.12574