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- Title
Prognostic factors indicating survival with native liver after Kasai procedure for biliary atresia.
- Authors
Obayashi, Juma; Kawaguchi, Kohei; Manabe, Shutaro; Nagae, Hideki; Wakisaka, Munechika; Koike, Junki; Takagi, Masayuki; Kitagawa, Hiroaki
- Abstract
<bold>Background: </bold>The number of the bile ducts in the portal canal/measured surface area of the portal canal (BDP ratio) indicates prognosis in biliary atresia (BA), as does an elevated cytokeratin 7 positivity percentage (PCK7). We compared these two markers.<bold>Methods: </bold>We reviewed 32 BA cases undergoing Kasai operation from 1976 to 2016 with >5 portal canals in biopsy samples. Group I required liver transplantation or died within a year of operation (n = 8). Group II survived with their native liver (n = 24). We determined the BDP ratio (102/mm2) and PCK7 (%), subdividing patients into three groups by their age at operation: Group A ≤60 days (n = 6, 1 Group I), 60< Group B ≤90days (n = 16, 5 Group I), Group C >90 days (n = 10, 2 Group I).<bold>Results: </bold>PCK7 (%) was 2.71 ± 1.87 in Group I and 4.25 ± 2.56 in Group II (p = 0.13). BDP ratio (102/mm2) was 1.19 ± 0.424 in Group I and 1.64 ± 0.534 in Group II (p = 0.04). Both markers were higher in Group C than in Group A or B (p < 0.01).<bold>Conclusion: </bold>The BDP ratio is a better prognostic indicator than PCK7 in BA.
- Subjects
PROGNOSIS; BILIARY atresia; BILE ducts; BIOMARKERS; BIOPSY; THERAPEUTICS; LIVER surgery; PROTEINS; SURVIVAL analysis (Biometry); SURGICAL anastomosis
- Publication
Pediatric Surgery International, 2017, Vol 33, Issue 10, p1047
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-017-4135-y