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- Title
The role of core needle biopsy in the diagnosis of initially detected thyroid nodules: a systematic review and meta-analysis.
- Authors
Chung, Sae Rom; Suh, Chong Hyun; Baek, Jung Hwan; Choi, Young Jun; Lee, Jeong Hyun
- Abstract
<bold>Objectives: </bold>To systematically review the published literature and evaluate the efficacy and safety of core needle biopsy (CNB) for initially detected thyroid nodules.<bold>Methods: </bold>The Ovid-MEDLINE and Embase databases were searched for studies evaluating CNB for the diagnosis of initially detected thyroid nodules. A meta-analysis was performed to evaluate non-diagnostic results, inconclusive results and diagnostic accuracy for a diagnosis of malignancy with CNB. To overcome heterogeneity, multiple subgroup analyses were performed. The complication rate was also evaluated.<bold>Results: </bold>Thirteen eligible studies, which included a total sample size of 9,166 patients with 13,585 nodules, were included. The pooled proportions were 3.5% (95% CI 2.4-5.1) for non-diagnostic results and 13.8% (95% CI 9.1-20.3) for inconclusive results. Considerable heterogeneity was observed among the studies in terms of the pooled proportions for CNB (I2=92.9%, 97%). With regard to the diagnostic performance for malignancy, the sensitivity was 80% (95% CI 75-85) and the specificity was 100% (95% CI 93-100). Only two major complications of CNB were observed.<bold>Conclusions: </bold>CNB demonstrates a low non-diagnostic result rate and high diagnostic accuracy for initially detected thyroid nodules and a low major complication rate. These findings indicate that CNB may be a feasible diagnostic tool for patients with initially detected thyroid nodules.<bold>Key Points: </bold>CNB demonstrates high diagnostic accuracy for initially detected thyroid nodules. CNB demonstrates a low major complication rate. CNB may be a feasible diagnostic tool for patients with initially detected thyroid nodules.
- Subjects
CORE needle biopsy; DIAGNOSTIC ultrasonic imaging; HETEROGENEITY; THYROID cancer treatment; THYROID cancer patients; BIOPSY; META-analysis; NEEDLE biopsy; THYROID gland tumors; SYSTEMATIC reviews
- Publication
European Radiology, 2018, Vol 28, Issue 11, p4909
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-018-5494-z