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- Title
Diffusion-weighted MRI, 11C-choline PET and 18F-fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma.
- Authors
Chang, Joe H; Lim Joon, Daryl; Lee, Sze Ting; Hiew, Chee-Yan; Esler, Stephen; Gong, Sylvia J; Wada, Morikatsu; Clouston, David; O'Sullivan, Richard; Goh, Yin P; Tochon-Danguy, Henri; Chan, J Gordon; Bolton, Damien; Scott, Andrew M; Khoo, Vincent; Davis, Ian D
- Abstract
<bold>Objectives: </bold>To evaluate the accuracy of transrectal ultrasound-guided (TRUS) biopsy, diffusion-weighted (DW) magnetic resonance imaging (MRI), (11)C-choline (CHOL) positron emission tomography (PET), and (18)F-fluorodeoxyglucose (FDG) PET in predicting the prostatectomy Gleason risk (GR).<bold>Methods: </bold>The study included 21 patients who underwent TRUS biopsy and multi-technique imaging before radical prostatectomy. Values from five different tests (TRUS biopsy, DW MRI, CHOL PET, FDG PET, and combined DW MRI/CHOL PET) were correlated with the prostatectomy GR using Spearman's ρ. Tests that were found to have significant correlations were used to classify patients into GR groups.<bold>Results: </bold>The following tests had significant correlations with prostatectomy GR: TRUS biopsy (ρ = 0.617, P = 0.003), DW MRI (ρ = -0.601, P = 0.004), and combined DW MRI/CHOL PET (ρ = -0.623, P = 0.003). CHOL PET alone and FDG PET only had weak correlations. The correct GR classification rates were 67% with TRUS biopsy, 67% with DW MRI, and 76% with combined DW MRI/CHOL PET.<bold>Conclusions: </bold>DW MRI and combined DW MRI/CHOL PET have significant correlations and high rates of correct classification of the prostatectomy GR, the strength and accuracy of which are comparable with TRUS biopsy.<bold>Key Points: </bold>• Accurate determination of the Gleason score is essential for prostate cancer management. • DW MRI ± CHOL PET correlated significantly with prostatectomy Gleason score. • These correlations are similar to that between TRUS biopsy and prostatectomy.
- Publication
European Radiology, 2014, Vol 24, Issue 3, p715
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-013-3045-1