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- Title
Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy.7 in naturally infected monkeys.
- Authors
Mori, S.; Takeuchi, T.; Enomoto, Y.; Kondo, K.; Sato, K.; Ono, F.; Sata, T.; Kanda, T.
- Abstract
Adeno-associated virus (AAV) is used in gene-therapy studies, but its tissue distribution is unknown in natural infection. We examined cynomolgus AAVs (previously isolated AAV10 and AAV11 and novel AAVcy.7) for their tissue distribution in 14 cynomolgi by type-specific PCR. We found AAV10, AAV11, and AAVcy.7 in 6, 10, and 14 monkeys, respectively, and two or three types in 11 monkeys, showing that these AAVs are widespread in the monkeys. We detected AAV at a higher level mainly in the lymphatic tissues and ileum, which suggests that AAV may invade the host through Peyer’s patches in the ileum and infect immune cells.
- Subjects
GENE therapy; KRA; VIRUS diseases; ILEUM diseases; CELLS
- Publication
Archives of Virology, 2008, Vol 153, Issue 2, p375
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-007-1097-8