We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Disrupted communication of the temporoparietal junction in patients with major depressive disorder.
- Authors
Wen, Xiaotong; Liu, Yuan; Zhao, Ping; Liu, Zhenghao; Li, Huanhuan; Li, Wen; Zhu, Zhiyuan; Wu, Xia
- Abstract
Patients with major depressive disorder (MDD) suffer impairment in the transmission and integration of internal and external information sources. Accumulating evidence suggests that the temporoparietal junction (TPJ) is important for multiple cognitive and social functions and may act as a key node for the integration of internal and external information. Therefore, the TPJ's aberrant interaction mechanism may underpin MDD psychopathology. To answer this question, we conducted a comprehensive study using resting-state functional magnetic imaging data recorded from 74 patients with MDD and 69 normal controls. First, we examined whether TPJ was the most prominent region with altered functional/effective connectivity with multiple depression-related regions/networks, based on either zero-lag correlations or temporal mutual information (total interdependence and Granger causality) measurements. Accordingly, we derived a network model that depicts alterations of TPJ-connectivity in patients with MDD. Lastly, we performed a cross-approach comparison demonstrating more conducive indicators in delineating the network alteration model. Functional/effective connectivity between the TPJ and major functional networks that govern internal and external-driven information resources was attenuated in patients with MDD. TPJ acts like a key node for information-inflow and integration of multiple information streams. Therefore, dysfunctional connectivity indicators may serve as effective biomarkers for MDD. MDD is associated with the breakdown of the TPJ interaction model and its connections with the default mode network and the task-positive network.
- Subjects
MENTAL depression; TEMPOROPARIETAL junction; DEFAULT mode network; COGNITIVE ability; SOCIAL skills
- Publication
Cognitive, Affective & Behavioral Neuroscience, 2021, Vol 21, Issue 6, p1276
- ISSN
1530-7026
- Publication type
Article
- DOI
10.3758/s13415-021-00918-5