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- Title
线粒体自噬在肠缺血再灌注损伤中的作用及机制研究进展.
- Authors
梅峻豪; 张嘉伟; 李绍钦; 王 凯; 贾中芝
- Abstract
Acute intestinal ischemic is a common and critical illness,such as superior mesenteric artery embolism. Ischemia reperfusion injury(IRI)is common after treatment. In the pathological process of intestinal IRI,mitophagy is a“double⁃edged sword”. Its role mainly depends on the degree of IRI. In the pathological changes of mild intestinal IRI,it plays a role in alleviating IRI,while in severe cases,it plays the opposite role. The regulation mechanism of mitophagy in intestinal IRI involves multiple signal pathways, such as PINK1/Parkin signal pathway,BNIP3/NIX signal pathway,FUNDC1 signal pathway and Beclin1 signal pathway. With the deepening of related research,the function and mechanism of mitophagy in intestinal IRI is gradually clear,which provides a reference for accurate intestinal IRI.
- Publication
Journal of Nanjing Medical University: Natural Sciences, 2022, Vol 42, Issue 8, p1188
- ISSN
1007-4368
- Publication type
Article
- DOI
10.7655/NYDXBNS20220822