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- Title
One-pot synthesis of 3,4-dihydropyridin-2-ones via tandem reaction of Blaise reaction intermediate and acrylic ester.
- Authors
Meng, Tuanjie; Liu, Lantao; Jia, Huiyi; Ren, Lifeng; Feng, Cuilan; Wang, Xiaojuan; Zhao, Wenxian
- Abstract
An efficient method for the synthesis 3,4-dihydropyridin-2-ones has been developed via tandem one-pot Michael-type addition and cyclization of the Blaise reaction intermediate and acrylic ester. A series of readily available nitriles, bromoacetic esters and acrylic esters have been employed to examine the scope of substrates for this method.
- Subjects
DIHYDROPYRIDINE; ACRYLIC compounds; NITRILE synthesis; RING formation (Chemistry); BIOACTIVE compounds
- Publication
Applied Organometallic Chemistry, 2016, Vol 30, Issue 1, p47
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.3399