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- Title
A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Ca<sub>v</sub>2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons.
- Authors
Park, Jin-Yong; Remy, Stefan; Varela, Juan; Cooper, Donald C.; Sungkwon Chung; Ho-Won Kang; Jung-Ha Lee; Spruston, Nelson
- Abstract
Activation of group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5) regulates neural activity in a variety of ways. In CA1 pyramidal neurons, activation of group I mGluRs eliminates the post-burst afterhyperpolarization (AHP) and produces an afterdepolarization (ADP) in its place. Here we show that upregulation of Cav2.3 R-type calcium channels is responsible for a component of the ADP lasting several hundred milliseconds. This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores. Effects of mGluR activation on subthreshold membrane potential changes are negligible but are large following action potential firing. Furthermore, the medium ADP exhibits a biphasic activity dependence consisting of short-term facilitation and longer-term inhibition. These findings suggest that mGluRs may dramatically alter the firing of CA1 pyramidal neurons via a complex, activity-dependent modulation of Cav2.3 R-type channels that are activated during spiking at physiologically relevant rates and patterns.
- Subjects
GLUTAMIC acid; NEURONS; PHOSPHOLIPASE C; CALCIUM channels; MODULATION theory; CALCIUM
- Publication
PLoS Biology, 2010, Vol 8, Issue 11, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.1000534