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- Title
Axon-Reflex-basierte Nervenmessverfahren in der Diagnostik autonomer Neuropathie.
- Authors
Siepmann, T.; Illigens, B.M.-W.; Reichmann, H.; Ziemssen, T.
- Abstract
Axon-reflex-based tests of peripheral small nerve fiber function including techniques to quantify vasomotor and sudomotor responses following acetylcholine iontophoresis are used in the assessment of autonomic neuropathy. However, the established axon-reflex-based techniques, laser Doppler flowmetry (LDF) to assess vasomotor function and quantitative sudomotor axon-reflex test (QSART) to measure sudomotor function, are limited by technically demanding settings as well as interindividual variability and are therefore restricted to specialized clinical centers. New axon-reflex tests are characterized by quantification of axon responses with both temporal and spatial resolution and include 'laser Doppler imaging (LDI) axon-reflex flare area test' to assess vasomotor function, the quantitative direct and indirect test of sudomotor function (QDIRT) to quantify sudomotor function, as well as the quantitative pilomotor axon-reflex test (QPART), a technique to measure pilomotor nerve fiber function using adrenergic cutaneous stimulation through phenylephrine iontophoresis. The effectiveness of new axon-reflex tests in the assessment of neuropathy is currently being investigated in clinical studies.
- Subjects
PERIPHERAL neuropathy diagnosis; DIAGNOSIS of autonomic nervous system diseases; DIAGNOSIS methods; VASOMOTOR system; GOOSEBUMPS (Physiology); IONTOPHORESIS; NEUROPATHY; DIAGNOSIS
- Publication
Der Nervenarzt, 2014, Vol 85, Issue 10, p1309
- ISSN
0028-2804
- Publication type
Article
- DOI
10.1007/s00115-014-4120-9