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- Title
Opinion: Reassessing the function of immune-complex retention by follicular dendritic cells.
- Authors
Haberman, Ann M.; Shlomchik, Mark J.
- Abstract
The close association of follicular dendritic cells (FDCs) and germinal-centre B cells has fostered the idea that B-cell recognition of retained antigen that is presented on the surface of FDCs is important for affinity maturation and memory B-cell development. We argue that the retention of immune complexes is not required for germinal-centre development, affinity maturation and memory B-cell maintenance. Instead, it is probable that FDCs support B-cell proliferation and differentiation in a non-specific manner. Other potential roles of immune complexes retained by FDCs are discussed.
- Subjects
DENDRITIC cells; B cells; ANTIGENS; ANTIGEN presenting cells; LYMPHOID tissue; IMMUNE system
- Publication
Nature Reviews Immunology, 2003, Vol 3, Issue 9, p757
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri1178