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- Title
Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages.
- Authors
Zong, Yao; Lin, Leilei; Yi, Changxian; Huang, Xia; Fu, Yue; Dong, Yanmin; Qian, Xiaobing; Li, Yujie; Gao, Qianying
- Abstract
Purpose: This study was conducted to determine whether oxygen saturation and retinal blood vessel diameter are affected by retinitis pigmentosa (RP) at various ages. Methods: Relative oxygen saturation was measured in retinal blood vessels in 68 RP patients and 136 normal subjects using the Oxymap T1 retinal oximeter. Subjects were divided into two age groups: Group A (20-40 years) and Group B (> 40 years). One randomly selected eye of each subject was used for statistical analysis. Student's t tests were used to analyze the mean saturation and diameter of retinal arterioles and venules and arteriovenous differences between RP and normal subjects in the two age groups. A Spearman test was used to analyze the correlation of mean saturation of retinal arterioles (AS) and arteriovenous differences (AVS) with visual acuity, disease duration, and electroretinogram (ERG) b-wave amplitude in patients with RP. Results: AS was significantly higher in patients with RP (105.5 ± 9.4 %) than in normal subjects (94.5 ± 4.4 %, p = 0.000) in Group A, while in Group B, AS was significantly lower in RP patients (86.8 ± 10.3 %) than in healthy subjects (96.0 ± 4.8 %, p = 0.000). Vessel diameter was smaller in RP patients than in normal subjects. AS and AVS showed a negative correlation with disease duration and a tendency toward positive correlation with ERG b-wave in patients with RP. Conclusions: The shifting characteristics of retinal vessel oxygen saturation suggest that the pathological mechanism of retinal oxygen metabolic disorder differs by age in patients with RP.
- Subjects
RETINAL blood vessel diseases; RETINITIS pigmentosa; VISUAL acuity; ELECTRORETINOGRAPHY; DISEASE duration; MEDICAL statistics; OXIMETRY; DISEASE risk factors; DIAGNOSIS
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2016, Vol 254, Issue 2, p243
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-015-3039-6