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- Title
Influence of the New FIGO Classification for Cervical Cancer on Patient Survival: A Retrospective Analysis of 265 Histologically Confirmed Cases with FIGO Stages IA to IIB.
- Authors
de Gregorio, Amelie; Widschwendter, Peter; Ebner, Florian; Friedl, Thomas Wolfram Paul; Huober, Jens; Janni, Wolfgang; de Gregorio, Nikolaus
- Abstract
Objective: At the end of the year 2018, a new FIGO classification for cervical cancer was published, mainly revising stage IB and introducing a new stage IIIC, which includes irrespectively of tumor size and local spread all patients with lymph node metastasis. Methods: We retrospectively analyzed all cases of cervical cancer stage I to IIB who underwent surgery as primary treatment at our institution from 2000 until 2016 and therefore had a histological confirmation of tumor stage. We reclassified all histologies according to the new FIGO classification and calculated outcome according to the new stages. Results: Out of 265 patients, 146 (55%) patients were reclassified into a higher FIGO stage. Most changes appeared within stage IB and from any stage to stage IIIC1. Kaplan-Meier curves for new stages showed a significant difference in disease-free survival (DFS) and overall survival (OS) between stages I versus II versus III (log-rank test, both p < 0.001). Overall, patients that were upstaged had a significant worse DFS (p = 0.012) and OS (p = 0.008) than patients whose stage did not change. Similar observations were made within sub-stages, when node-positive IB or IIB tumors were upstaged to IIIC tumors. Conclusion: The new FIGO classification for cervical cancer reflects the strong impact of lymph node metastases on survival and is a clear improvement compared to the old FIGO classification with regard to risk stratification.
- Subjects
ILLINOIS; CONFERENCES &; conventions; HISTOLOGICAL techniques; LYMPH nodes; METASTASIS; PROFESSIONAL associations; RISK assessment; SURVIVAL; TUMOR classification; CERVIX uteri tumors; RETROSPECTIVE studies; KAPLAN-Meier estimator; LOG-rank test
- Publication
Oncology, 2020, Vol 98, Issue 2, p91
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000503149