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- Title
Repeated Passive Mobilization to Stimulate Vascular Function in Individuals of Advanced Age Who Are Chronically Bedridden: A Randomized Controlled Trial.
- Authors
Pedrinolla, Anna; Magliozzi, Roberta; Colosio, Alessandro L; Danese, Elisa; Gelati, Matteo; Rossi, Stefania; Pogliaghi, Silvia; Calabrese, Massimiliano; Muti, Ettore; Cè, Emiliano; Longo, Stefano; Esposito, Fabio; Lippi, Giuseppe; Schena, Federico; Venturelli, Massimo
- Abstract
<bold>Background: </bold>Vascular dysfunction and associated disorders are major side effects of chronic bed rest, yet passive mobilization as a potential treatment has only been theorized so far. This study investigated the effects of passive mobilization treatment on vascular function in older, chronically bedridden people.<bold>Method: </bold>The study sample was 45 chronically bedridden people of advanced age (mean age: 87 years; 56% female; mean bed rest: 4 years) randomly assigned to a treatment (n = 23) or a control group (CTRL, n = 22). The treatment group received passive mobilization twice daily (30 minutes, 5 times/wk) for 4 weeks. A kinesiologist performed passive mobilization by passive knee flexion/extension at 1 Hz in one leg (treated leg [T-leg] vs control leg [Ctrl-leg]). The CTRL group received routine treatment. The primary outcome was changes in peak blood flow (∆peak) as measured with the single passive leg movement test at the common femoral artery.<bold>Results: </bold>∆Peak was increased in both legs in the Treatment group (+90.9 mL/min, p < .001, in T-leg and +25.7 mL/min, p = .039 in Ctrl-leg). No difference in peak blood flow after routine treatment was found in the CTRL group.<bold>Conclusion: </bold>Improvement in vascular function after 4 weeks of passive mobilization was recorded in the treatment group. Passive mobilization may be advantageously included in standard clinical practice as an effective strategy to treat vascular dysfunction in persons with severely limited mobility.
- Subjects
RANDOMIZED controlled trials; BED rest; FEMORAL artery; BLOOD flow; LEG physiology; RESEARCH; RANGE of motion of joints; RESEARCH methodology; EVALUATION research; COMPARATIVE studies; BODY movement; RESEARCH funding; HEMODYNAMICS; STATISTICAL sampling
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2022, Vol 77, Issue 3, p588
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glab148