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- Title
Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles.
- Authors
Gittard, Shaun D.; Miller, Philip R.; Chunming Jin; Martin, Timothy N.; Boehm, Ryan D.; Chisholm, Bret J.; Stafslien, Shane J.; Daniels, Justin W.; Cilz, Nicholas; Monteiro-Riviere, Nancy A.; Nasir, Adnan; Narayan, Roger J.
- Abstract
Microneedles are small-scale needle-like projections that may be used for transdermal delivery of pharmacologic agents, including protein-containing and nucleic acid-containing agents. Commercial translation of polymeric microneedles would benefit from the use of facile and cost effective fabrication methods. In this study, visible light dynamic mask microstereolithography, a rapid prototyping technique that utilizes digital light projection for selective polymerization of a liquid resin, was used for fabrication of solid microneedle array structures out of an acrylate-based polymer. Pulsed laser deposition was used to deposit silver and zinc oxide coatings on the surfaces of the visible light dynamic mask microstereolithography-fabricated microneedle array structures. Agar diffusion studies were used to demonstrate the antimicrobial activity of the coated microneedle array structures. This study indicates that light-based technologies, including visible light dynamic mask microstereolithography and pulsed laser deposition, may be used to fabricate microneedles with antimicrobial properties for treatment of local skin infections.
- Subjects
PULSED laser deposition; ANTI-infective agents; SKIN disease treatment; STAPHYLOCOCCUS aureus infections; THIN film devices; POLYMERIC drugs; POLYMERIZATION; THERAPEUTICS
- Publication
JOM: The Journal of The Minerals, Metals & Materials Society (TMS), 2011, Vol 63, Issue 6, p59
- ISSN
1047-4838
- Publication type
Article
- DOI
10.1007/s11837-011-0093-3