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- Title
Reduction in Muscle Glycogen and Protein Utilization with Glucose Feeding During Exercise.
- Authors
van Hamont, Dennis; Harvey, Christopher R.; Massicotte, Denis; Frew, Russell; Peronnet, François; Rehrer, Nancy J.
- Abstract
Effects of feeding glucose on substrate metabolism during cycling were studied. Trained (60.0 ± 1.9 mL · kg-1 · min-1) males (N = 5) completed two 75 min, 80% VO2max trials: 125 g 13C-glucose (CHO); 13C-glucose tracer, 10 g (C). During warm-up (30 min 30% VO2max) 2 · 2 g 13C-glucose was given as bicarbonate pool primer. Breath samples and blood glucose were analyzed for 13C/12C with IRMS. Protein oxidation was estimated from urine and sweat urea. Indirect calorimetry (protein corrected) and 13C/12C enrichment in expired CO2 and blood glucose allowed exogenous (Gexo), endogenous (Gendo), muscle (Gmuscle), and liver glucose oxidation calculations. During exercise (75 min) in CHO versus C (respectively): protein oxidation was lower (6.8 ± 2.7, 18.8 ± 5.9 g; P = 0.01); Gendo was reduced (71.2 ± 3.8, 80.7 ± 5.7%; P = 0.01); Gmuscle was reduced (55.3 ± 6.1, 65.9 ± 6.0%; P = 0.01) compensated by increased Gexo (58.3 ± 2.1, 3.87 ± 0.85 g; P = 0.000002). Glucose ingestion during exercise can spare endogenous protein and carbohydrate, in fed cyclists, without glycogen depletion.
- Subjects
GLUCOSE; METABOLISM; GLYCOGEN; EXERCISE; NUTRITION; HEALTH
- Publication
International Journal of Sport Nutrition & Exercise Metabolism, 2005, Vol 15, Issue 4, p350
- ISSN
1526-484X
- Publication type
Article
- DOI
10.1123/ijsnem.15.4.350