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- Title
UV和 PMA引起的炎症敏感性皮肤的体外 功效评估方法研究.
- Authors
周春霞; 邹岳
- Abstract
Sensitive skin has become an increasingly concerned skin problem in the global skin care product market. Sensitive skin caused by inflammation is on the increase. Therefore, the development of skin care products for inflammation-sensitive skin has become an important way to solve this problem. In this work, an in vitro research platform for cosmetic raw materials was established for inflammatory sensitive skin caused by ultraviolet (UV) radiation and PMA (PHORBOL 12-MYRISTATE 13-ACETATE), which might provide support for the development of functional ingredients for sensitive skin care. The inflammation model was established with human epidermal primary keratinocytes. UV radiation and PMA were used to stimulate human primary keratinocytes. The release of inflammatory factors TNF-a and IL-1a was measured by enzyme-linked immunosorbent assay method to determine the effectiveness of the inflammation model. The results show that, the relative content of inflammatory factors is increased to varying degrees in both cases of UV radiation and PMA, so the inflammation model can be further verified with functional components. Dexamethasone was used as a positive reference material, and dipotassium glycyrrhizinate, bisabolol, and portulaca were used as active materials to verify the effectiveness of the model. The results show that dipotassium glycyrrhizinate and bisabolol can inhibit UV and PMA-mediated production of TNF-a and IL-1a to varying degrees, thereby reducing the occurrence of skin sensitivity. The inflammation model is good in verifying the effects of functional components on inflammatory factors. Therefore, the inflammation model can provide experimental data support for the development of functional components for care of sensitive skin.
- Publication
Detergent & Cosmetics, 2021, Vol 44, Issue 12, p31
- ISSN
1006-7264
- Publication type
Article
- DOI
10.3969/j.issn.1006-7264.2021.12.008