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- Title
The Effect of Folic Acid Supplementation on Endothelial Function and Arterial Stiffness Markers in Adults: A Systematic Review and Meta-Analysis.
- Authors
Bokayeva, Kamila; Jamka, Małgorzata; Banaszak, Michalina; Makarewicz-Bukowska, Aleksandra; Adamczak, Ada; Chrobot, Maria; Janicka, Adrianna; Jaworska, Natalia; Walkowiak, Jarosław
- Abstract
Folic acid might improve endothelial function, but the results are inconclusive. This systematic review evaluated the effect of folic acid supplementation on endothelial parameters and arterial stiffness in adults. The study protocol was registered with the PROSPERO database (CRD42021290195). The PubMed, Web of Sciences, Cochrane and Scopus databases were searched to identify English-language randomised controlled trials of the effect of folate supplementation on arterial stiffness and endothelial function markers in adults. There were significant differences between the effect of folic acid and placebo on flow-mediated dilation (random-effects model, standardized mean differences (SMD): 0.888, 95% confidence interval (CI): 0.447, 1.329, p < 0.001) and monocyte chemotactic protein 1 (random-effects model, SMD: −1.364, 95% CI: −2.164, −0.563, p < 0.001), but there was no significant difference in the central pulse wave velocity (fixed-effects model, SMD: −0.069, 95% CI: −0.264, 0.125, p = 0.485) and peripheral pulse wave velocity (fixed-effects model, SMD: −0.093, 95% CI: −0.263, 0.077, p = 0.284). In conclusion, folic acid might have a favourable effect on endothelial function but may not affect arterial stiffness. Further studies are needed to confirm these results.
- Subjects
THERAPEUTIC use of folic acid; ENDOTHELIAL cells; BIOMARKERS; ONLINE information services; MEDICAL databases; META-analysis; ENDOTHELIUM; SYSTEMATIC reviews; DIETARY supplements; ARTERIAL diseases; TREATMENT effectiveness; VASODILATION; PULSE wave analysis; BLOOD circulation; DESCRIPTIVE statistics; MEDLINE; CHEMOKINES; INFLAMMATORY mediators; DATA analysis software; MONOCYTES; EVALUATION
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 18, p2524
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11182524