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- Title
Long-Term Effects of Subthalamic Stimulation on Motor Symptoms and Quality of Life in Patients with Parkinson's Disease.
- Authors
Jiang, Jiin-Ling; Chen, Shin-Yuan; Tsai, Sheng-Tzung; Ma, Yu-Chin; Wang, Jen-Hung
- Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting both motor functions and quality of life (QoL). This study compared motor symptoms and QoL in patients with PD before and at 1 and 5 years after subthalamic nucleus deep brain stimulation (STN-DBS) surgery in Taiwan. This study included 53 patients with PD undergoing STN-DBS. The motor symptoms improved by 39.71 ± 26.52% and 18.83 ± 37.15% in the Unified Parkinson's Disease Rating Scale (UPDRS) part II and by 36.83 ± 22.51% and 22.75 ± 36.32% in the UPDRS part III at 1 and 5 years after STN-DBS in the off-medication/on-stimulation state, respectively. The Hoehn and Yahr stage significantly improved at the 1-year follow-up but declined progressively and returned to the baseline stage 5 years post-surgery. The Schwab and England Activities of Daily Living improved and sustained for 5 years following STN-DBS. Levodopa equivalent daily dose decreased by 35.32 ± 35.87% and 15.26 ± 65.76% at 1 and 5 years post-surgery, respectively. The QoL revealed significant improvement at 1 year post-surgery; however, patients regressed to near baseline levels 5 years post-surgery. The long-term effects of STN-DBS on motor symptoms were maintained over 5 years after STN-DBS surgery. At the same time, STN-DBS had no long-lasting effect on QoL. The study findings will enable clinicians to become more aware of visible and invisible manifestations of PD.
- Subjects
TAIWAN; DRUG therapy for Parkinson's disease; DEEP brain stimulation; PATIENT aftercare; BRAIN; DIENCEPHALON; SCIENTIFIC observation; DOPA; MAGNETIC resonance imaging; MANN Whitney U Test; T-test (Statistics); QUALITY of life; QUESTIONNAIRES; DESCRIPTIVE statistics; COMPUTED tomography; DATA analysis software; LONGITUDINAL method; PROBABILITY theory
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 6, p920
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11060920