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- Title
慢性肾脏病- 矿物质和骨代谢紊乱导致血管钙化的分子机制研究进展.
- Authors
施晴波; 端颖; 邱郁梅; 徐静; 何伟春
- Abstract
Chronic kidney disease-mineral and bone disorder (CKD-MBD)-rnduced vascular calcification has been proved to be an independent risk factor of cardiovascular events in patients with chronic kidney disease (CKD). Impaired calcium and phosphate homeostasis, increased oxidative stress, loss of calcification inhibitors and increased expression of RANKL are related to the vascular calcification in CKD. Additionally, impaired bone may be implicated in the pathogenesis of vascular calcification through perturbing serum calcium phosphate and parathyroid hormone, thus contributing to increased vascular calcification in CKD. Therapeutic approaches for CKD. such as phosphate binders and bisphosphonates. have been shown to ameliorate bone loss as well as vascular calcification. This article reviews recent progress of the pathogenesis of vascular calcification in CKD-MBD.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 10, p1996
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.10.040