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- Title
口腔扁平苔藓患者的 CIITA 基因单倍型分析.
- Authors
屈爽; 苗运博; 吴丹; 孙茂; 刘青; 杨安钢; 吴元明; 王立锋
- Abstract
Objective: This study analyses the relationship between OLP and haplotype composed of SNPs in CIITA, and develops a new method of haplotype analysis. Methods: With the SNPs information of a case group of 42 and a control group of 86, we use haploview and SHEsis to analyze haplotype. When compare group data. Chi-square test is used which takes p=0.05 as the statistical significance threshold.Results:In the cohort, 15 SNPs of the CIITA gene formed 2 haploblocks, in which rs6498124, rs11647384, rs4774 compose a haplotype GAC. This haplotype showed statistical significance in each analyzing method (Haploview: Chi2=6.127, P=0.013 SHEsis: Chi2= 6.469, P=0.011 frequency-counting: Chi2=5.460, P=0.019)Conclusion:In a haploblock composed of rs6498124, rs11647384and rs4774 in CIITA, the haplotype GAC showed potential protection for OLP. The analysis from frequency-counting showed that the protection of rs4774 itself and its linkage disequilibrium relationship with other sites in the same haploblock contribute to the protection of haplotype GAC. And indicate that haplotype explanation for disease susceptivity may rely on the allelotype of certain significant SNP site and its linkage disequilibrium relationship with other related sites.
- Publication
Progress in Modern Biomedicine, 2015, Vol 15, Issue 25, p4813
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2015.25.004