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- Title
Synthesis, characterization, and biological activity of transition metals complexes with mefenamic acid (NSAIDs).
- Authors
Ramzan, S.; Saleem, S.; Mirza, B.; Ali, S.; Ahmed, F.; Shahzadi, S.
- Abstract
A new series of transition metal complexes have been synthesized with [(2,3-dimethylphenyl)-amino]benzoic acid (Mefenamic acid) in 1 : 1/1 : 2 M : L ratio. The complexes have been characterized by elemental analysis, FT-IR and UV-Vis spectroscopy. Antifungal, antibacterial, antitumor, antioxidant (DPPH, HO induced DNA damage) activity of the complexes and DNA interaction with the complexes were studied. The results revealed that the ligand and most of synthesized compounds did not demonstrate significant antibacterial activity unlike [Ni(Mef)(HO)Cl] that exhibited pronounced activity against F. Solani. Antitumor activity of the products was higher than that of the free ligand.
- Subjects
TRANSITION metals; COMPLEX compounds; BENZOIC acid; MEFENAMIC acid; ANTIBACTERIAL agents; ANTIOXIDANTS; DNA damage
- Publication
Russian Journal of General Chemistry, 2015, Vol 85, Issue 7, p1745
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363215070282