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- Title
Instrumentation and Technique for Delivery of Tissue Explants to the Subretinal Space.
- Authors
Gabriele Thumann; Sabin Aisenbrey; Frank Schaefer; Karl Ulrich Bartz-Schmidt
- Abstract
AbstractPurpose: The controlled orientation of subretinal or intraretinal delivery of delicate tissue sheets is a critical problem in retinal transplantation research. Methods: A surgical device (explant injector) was designed and built for the controlled delivery of tissue explants into the subretinal or intraretinal space via a vitrectomy approach. The technical feasibility was demonstrated in enucleated porcine eyes. Results: Using negative pressure, the injector allows for the fixation of an explant, such as a monolayer of cells cultured on a collagen membrane, on the carrier platform. The sheet can then be placed safely without loss of orientation in the subretinal space. Conclusions: With the aid of the explant injector, it is possible to deliver an explant with the proper orientation to a precise location in the subretinal space.Copyright © 2006 S. Karger AG, Basel
- Subjects
TRANSPLANTATION of organs, tissues, etc.; TISSUES; VITRECTOMY; COLLAGEN; SURGERY
- Publication
Ophthalmologica, 2006, Vol 220, Issue 3, p170
- ISSN
0030-3755
- Publication type
Article
- DOI
10.1159/000091760