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- Title
Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage.
- Authors
Seul Gi Park; Hyo Ju Yang; Soo Yeon Lim; Seh Hyun Kim; Seung Han Shin; Ee-Kyung Kim; Han-Suk Kim
- Abstract
Purpose: Extremely preterm infants are prone to brain injury and underdevelopment. Intraventricular hemorrhage (IVH) is the most common cause of brain injury and a significant risk factor for neurodevelopmental delay in preterm infants. Severe IVH is known to have a poor outcome; however, the outcomes of low-grade IVH remain controversial. This study aimed to evaluate neurodevelopmental outcomes and brain segmental volumes of preterm infants with low-grade IVH. Methods: This retrospective cohort study included 109 extremely preterm infants who underwent term equivalent age-magnetic resonance imaging and neurodevelopmental evaluation at a corrected age of 18 to 24 months. We compared infants with and without low-grade IVH. Results: Among the 109 extremely preterm infants, 25 had low-grade IVH and 84 had no IVH. There were no significant differences in the neurodevelopmental outcomes between the low-grade and no IVH groups. In multivariate analysis, low-grade IVH was associated with a smaller medullary volume (adjusted odds ratio, 0.575; 95% confidence interval, 0.346 to 0.957; P=0.034). Conclusion: We found no significant differences in the neurodevelopmental outcomes of extremely preterm infants at a corrected age of 18 to 24 months between those with low-grade IVH and those without IVH. Low-grade IVH was associated with a smaller medullary volume.
- Subjects
NEURODEVELOPMENTAL treatment for infants; INTRAVENTRICULAR hemorrhage; VOLUMETRIC analysis; PREMATURE infants; NEURAL development; INJURY risk factors; BRAIN injuries
- Publication
Neonatal Medicine, 2023, Vol 30, Issue 2, p42
- ISSN
2287-9412
- Publication type
Article
- DOI
10.5385/nm.2023.30.2.42