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- Title
HO-SAS catalyzed protection and deprotection of aldehydes and alcohols in continuous flow reactors.
- Authors
Fukuyama, Takahide; Hirano, Toshiaki; Takamura, Kengo
- Abstract
We investigated the flow acetalization of aldehydes and THP protection of alcohols using sulfonic acid-functionalized silica gel having hydroxy moiety (HO-SAS) as the solid acid catalyst. The reaction both aliphatic and aromatic aldehydes reacted with methanol within 5 min of residence time to give acetalization product in good to excellent yield. THP protection of primary, secondary, and tertiary alcohols proceeded well to the corresponding products. Both reactions did not require a neutralization process. Scalable syntheses were also achieved with continuous operation. The deprotection reactions were also effective using HO-SAS packed flow reactors.
- Subjects
CONTINUOUS flow reactors; ALDEHYDES; AROMATIC aldehydes; ACID catalysts; HYDROXYCINNAMIC acids; SILICA gel
- Publication
Journal of Flow Chemistry, 2024, Vol 14, Issue 1, p297
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-023-00298-6