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- Title
Chronic Evaluation of the Cleveland Clinic CorAide Left Ventricular Assist System in Calves.
- Authors
Fukamachi, Kiyotaka; Ochiai, Yoshie; Doi, Kazuyoshi; Massiello, Alex L; Medvedev, Alexander L; Horvath, David J; Gerhart, Renee L; Chen, Ji-Feng; Krogulecki, Alexandra Y; Takagaki, Masami; Howard, Michael W; Kopcak, Michael W; Golding, Leonard A.R
- Abstract
The Cleveland Clinic CorAide left ventricular assist system is based on a third-generation, implantable, centrifugal pump in which a rotating assembly is suspended fully. To evaluate chronic in vivo system performance and biocompatibility, the CorAide blood pump was implanted in 18 calves for either 1 month or 3 months. Hemodynamics were stable in all calves with a mean pump flow of 5.9 ± 1.2 L/min and a mean systemic arterial pressure of 98 ± 5 mm Hg. There were no incidences of bleeding, organ dysfunction, or mechanical failure in any of the 18 calves. Hemolysis occurred in only 1 calf due to outflow graft stenosis. Thrombus inside the pump, seen in 4 of the first 6 cases, was totally eliminated by a final redesign in the remaining cases, including the last 6 implants conducted without anticoagulation therapy. The CorAide blood pump demonstrated good biocompatibility and reliable, effective system performance.
- Subjects
ARTIFICIAL implants; LEFT heart ventricle
- Publication
Artificial Organs, 2002, Vol 26, Issue 6, p529
- ISSN
0160-564X
- Publication type
Article
- DOI
10.1046/j.1525-1594.2002.06994.x