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- Title
The genomics of major psychiatric disorders in a large pedigree from Northern Sweden.
- Authors
Szatkiewicz, Jin; Crowley, James J.; Adolfsson, Annelie Nordin; Åberg, Karolina A.; Alaerts, Maaike; Genovese, Giulio; McCarroll, Steven; Del-Favero, Jurgen; Adolfsson, Rolf; Sullivan, Patrick F.
- Abstract
We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.
- Publication
Translational Psychiatry, 2019, Vol 9, Issue 1, p1
- ISSN
2158-3188
- Publication type
Article
- DOI
10.1038/s41398-019-0414-9