We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer's Disease.
- Authors
Eren, Erden; Leoutsakos, Jeannie-Marie; Troncoso, Juan; Lyketsos, Constantine G.; Oh, Esther S.; Kapogiannis, Dimitrios
- Abstract
The hallmarks of Alzheimer's disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanisms are involved in AD, especially synaptic degeneration, which necessitate the need for synaptic integrity-related biomarkers alongside Aβ- and tau-related biomarkers. Plasma neuron-derived Extracellular Vesicles EVs (NDEVs) provide biomarkers related to Aβ and tau and synaptic degeneration. Here, to further establish the latter as a "liquid biopsy" for AD, we examined their relationship with ante-mortem cognition in pathologically-confirmed AD cases. We immunoprecipitated NDEVs by targeting neuronal marker L1CAM from ante-mortem plasma samples from 61 autopsy-confirmed cases of pure AD or AD with additional pathologies and measured Aβ42, p181-Tau, total Tau, synaptophysin, synaptopodin and three canonical EV markers, CD63, CD81 and CD9. Higher NDEV Aβ42 levels were consistently associated with better cognitive status, memory, fluency, working memory and executive function. Higher levels of NDEV synaptic integrity-related biomarkers were associated with better performance on executive function tasks. Our findings motivate the hypothesis that releasing Aβ42-laden NDEVs may be an adaptive mechanism in AD.
- Subjects
NEUROFIBRILLARY tangles; ALZHEIMER'S disease; COGNITION disorders; TAU proteins; EXTRACELLULAR vesicles; EXECUTIVE function
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 3, p436
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11030436