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- Title
Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites.
- Authors
Magalhães Rebelo, Ana Paula; Dal Bello, Federica; Knedlik, Tomas; Kaar, Natasha; Volpin, Fabio; Shin, Sang Hun; Giacomello, Marta
- Abstract
Contact sites between mitochondria and endoplasmic reticulum (ER) are points in which the two organelles are in close proximity. Due to their structural and functional complexity, their exploitation as pharmacological targets has never been considered so far. Notwithstanding, the number of compounds described to target proteins residing at these interfaces either directly or indirectly is rising. Here we provide original insight into mitochondria–ER contact sites (MERCs), with a comprehensive overview of the current MERCs pharmacology. Importantly, we discuss the considerable potential of MERCs to become a druggable target for the development of novel therapeutic strategies.
- Subjects
MITOCHONDRIAL membranes; ORGANELLES; PHARMACOLOGY
- Publication
Cells (2073-4409), 2020, Vol 9, Issue 7, p1637
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells9071637