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- Title
Green Synthesis of Spirooxindoles via Lipase-Catalyzed One-Pot Tandem Reaction in Aqueous Media.
- Authors
Tang, Yong; Wang, Ciduo; Xie, Hanqing; Xu, Yuelin; Wang, Chunyu; Du, Chuang; Wang, Zhi; Wang, Lei
- Abstract
The development of non-natural enzymatic catalysis is important for multicomponent tandem organic transformations. However, the delicate acting environments of biological enzymes still present some challenges in the synthesis of spirooxindole skeleton via enzymatic catalysis. To address these issues, a lipase-catalyzed method was developed for the synthesis of spirooxindole frameworks. Using easily available isatins, cycloketones, and malononitriles as substrates, mild reaction conditions, and a reasonable reaction time, moderate to good yields (67–92%) and excellent functional group tolerance were accomplished via this protocol. The related mechanism explanation is also speculated in this paper.
- Subjects
FUNCTIONAL groups; CATALYSIS; BIOCATALYSIS; KINETIC resolution
- Publication
Catalysts (2073-4344), 2023, Vol 13, Issue 1, p143
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal13010143