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- Title
DIM-1, a Novel Immunoglobulin Superfamily Protein in Caenorhabditis elegans, Is Necessary for Maintaining Bodywall Muscle Integrity.
- Authors
Rogalski, Teresa M.; Gilbert, Mary M.; Devenport, Danelle; Norman, Kenneth R.; Moerman, Donald G.
- Abstract
The UNC-112 protein is required during initial muscle assembly in C elegans to form dense bodies and M-lines. Loss of this protein results in arrest at the twofold stage of embryogenesis. In contrast, a missense mutation in unc-112 results in viable animals that have disorganized bodywall muscle and are paralyzed as adults. Loss or reduction of dim-1 gene function can suppress the severe muscle disruption and paralysis exhibited by these mutant hermaphrodites. The overall muscle structure in hermaphrodites lacking a functional dim-1 gene is slightly disorganized, and the myofilament lattice is not as strongly anchored to the muscle cell membrane as it is in wild-type muscle. The dim-1 gene encodes two polypeptides that contain three Ig-like repeats. The short DIM-1 protein isoform consists entirely of three Ig repeats and is sufficient for wild-type bodywall muscle structure and stability. DIM-1 (S) localizes to the region of the muscle cell membrane around and between the dense bodies, which are the structures that anchor the actin filaments and may play a role in stabilizing the thin rather than the thick filament components of the sarcomere.
- Subjects
IMMUNOGLOBULINS; CAENORHABDITIS elegans; MUSCLE proteins
- Publication
Genetics, 2003, Vol 163, Issue 3, p905
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1093/genetics/163.3.905