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- Title
Efficacy of vitamin D supplementation in combination with conventional antiviral therapy in patients with chronic hepatitis C infection: a meta‐analysis of randomised controlled trials.
- Authors
Kim, H.‐B.; Myung, S.‐K.; Lee, Y.‐J.; Park, B.‐J.; the Korean Meta‐Analysis (KORMA) Study Group
- Abstract
Abstract: Background: Although a contributory role of vitamin D levels for the development of chronic hepatitis C has been suggested, the efficacy of vitamin D supplementation in combination with conventional antiviral therapy consisting of pegylated interferon‐α (Peg‐IFN‐α) injection and oral ribavirin (RBV) remains unclear. We investigated its efficacy in the treatment of chronic hepatitis C via a meta‐analysis of randomised controlled trials. Methods: We searched PubMed, EMBASE, the Cochrane Library, ClinicalTrials.gov and the bibliographies of relevant articles to locate additional publications in September 2016. Three evaluators independently reviewed and selected eligible studies based on predetermined selection criteria. Results: Of 522 articles meeting our initial criteria, a total of seven open‐label, randomised controlled trials involving 548 participants, were included in the final analysis. Vitamin D supplementation in combination with Peg‐IFN‐α injection and oral RBV significantly increased the rate of viral response for hepatitis C at 24 weeks after treatment in a random‐effects meta‐analysis (relative risk = 1.30; 95% confidence interval = 1.04–1.62; <italic>I</italic>2 = 75.9%). Also, its significant efficacy was observed in patients with hepatitis C virus genotype 1, which is known to be refractory to antiviral therapy. Conclusions: In summary, we observed that additional use of vitamin D has a positive effect on sustained viral response rates of patients with chronic hepatitis C infection. However, we cannot establish the efficacy because of substantial heterogeneity, a small sample size and a low methodological quality.
- Subjects
THERAPEUTIC use of interferons; RIBAVIRIN; THERAPEUTIC use of vitamin D; ANTIVIRAL agents; CHRONIC hepatitis C; CONFIDENCE intervals; DIETARY supplements; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDICAL information storage &; retrieval systems; MEDLINE; META-analysis; ONLINE information services; SYSTEMATIC reviews; EVIDENCE-based medicine; PROFESSIONAL practice; STATISTICAL significance; RANDOMIZED controlled trials; RELATIVE medical risk; DESCRIPTIVE statistics; GENOTYPES; EVALUATION; THERAPEUTICS
- Publication
Journal of Human Nutrition & Dietetics, 2018, Vol 31, Issue 2, p168
- ISSN
0952-3871
- Publication type
Article
- DOI
10.1111/jhn.12503