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- Title
Exposure to 835 MHz RF-EMF decreases the expression of calcium channels, inhibits apoptosis, but induces autophagy in the mouse hippocampus.
- Authors
Ju Hwan Kim; Uy Dong Sohn; Hyung-Gun Kim; Hak Rim Kim
- Abstract
The exponential increase in the use of mobile communication has triggered public concerns about the potential adverse effects of radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phones on the central nervous system (CNS). In this study, we explored the relationship between calcium channels and apoptosis or autophagy in the hippocampus of C57BL/6 mice after RF-EMF exposure with a specific absorption rate (SAR) of 4.0 W/kg for 4 weeks. Firstly, the expression level of voltage-gated calcium channels (VGCCs), a key regulator of the entry of calcium ions into the cell, was confirmed by immunoblots. We investigated and confirmed that pan-calcium channel expression in hippocampal neurons were significantly decreased after exposure to RF-EMF. With the observed accumulation of autolysosomes in hippocampal neurons via TEM, the expressions of autophagyrelated genes and proteins (e.g., LC3B-II) had significantly increased. However, downregulation of the apoptotic pathway may contribute to the decrease in calcium channel expression, and thus lower levels of calcium in hippocampal neurons. These results suggested that exposure of RF-EMF could alter intracellular calcium homeostasis by decreasing calcium channel expression in the hippocampus; presumably by activating the autophagy pathway, while inhibiting apoptotic regulation as an adaptation process for 835 MHz RF-EMF exposure.
- Subjects
ELECTROMAGNETIC fields &; health; RADIO frequency; CENTRAL nervous system diseases; CALCIUM channels; CELL death; AUTOPHAGY; DISEASE risk factors
- Publication
Korean Journal of Physiology & Pharmacology, 2018, Vol 22, Issue 3, p277
- ISSN
1226-4512
- Publication type
Article
- DOI
10.4196/kjpp.2018.22.3.277