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- Title
Simultaneous angiotensin converting enzyme inhibition moderates ventricular dysfunction caused by doxorubicin
- Authors
Vaynblat, Mikhail; Shah, Himansu R.; Bhaskaran, Dinesh; Ramdev, Geeta; Davis III, Wellington J.; Cunningham Jr., Joseph N.; Chiavarelli, Mario; Davis, Wellington J 3rd; Cunningham, Joseph N Jr
- Abstract
Aims: The purpose of this study was to determine that the administration of an angiotensin converting enzyme (ACE) inhibitor enalapril would confer protection against doxorubicin-induced experimental heart failure, and attenuate the development of left ventricular dysfunction. Methods: Seventeen dogs were chronically instrumented with an intracoronary catheter and received doxorubicin weekly for 4 weeks. Animals were assigned to two groups: group 1: untreated heart failure; and group 2: simultaneous enalapril administration (5 mg twice a week). Hemodynamic data were obtained at week 0 and 12. Echocardiography was performed weekly. Results: Survival improved with simultaneous enalapril administration (36% in group 1 vs. 100% in group 2, P=0.04). The increase in the left ventricular end-diastolic pressure was significantly reduced at week 12 (17±1 mmHg in group 1 vs. 9±1 mmHg in group 2, P=0.0042). The fall in left ventricular stroke work index was significantly prevented (52% in group 1 vs. 21% in group 2, P=0.006). The increase in right ventricular end-diastolic diameter was significantly reduced by enalapril prophylaxis. Conclusion: Simultaneous treatment with enalapril was beneficial in the prevention of doxorubicin-induced cardiomyopathy.
- Subjects
ANGIOTENSIN converting enzyme; DOXORUBICIN; HEART failure; VENTRICULAR fibrillation; ACE inhibitors; ENALAPRIL; HEART ventricle diseases; ANIMAL experimentation; ANTINEOPLASTIC agents; BIOLOGICAL models; BLOOD pressure; COMPARATIVE studies; DOGS; LEFT heart ventricle; HEART beat; VASCULAR resistance; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TIME; EVALUATION research; TREATMENT effectiveness; STROKE volume (Cardiac output); THERAPEUTICS
- Publication
European Journal of Heart Failure, 2002, Vol 4, Issue 5, p583
- ISSN
1388-9842
- Publication type
journal article
- DOI
10.1016/S1388-9842(02)00091-0