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- Title
Simulation and experimental analysis of an intelligent tissue for controlled drug delivery.
- Authors
Barati, Aboulfazl; Sotoudeh, Saman; Davarnejad, Reza; Farahani, Mohammad Aliabadi
- Abstract
In this research, an antibiotic was loaded in the composites of polyethylene glycol (PEG), acrylamide (AAm) and acrylic acid (AAc) hydrogels matrices and their drug deliveries were tested. Effect of some parameters on the drug delivery was checked by UV-spectrophotometer. Temperature enhancement considerably increased hydrogel swelling and the drug release in the AAc and AAm. A dynamic model based on the Maxwell-Stefan equation was developed to model the drug delivery of hydrogels. COMSOL software was also applied to simulate buffer diffusion inside the hydrogels.
- Subjects
ANTIBIOTICS; POLYETHYLENE glycol; ACRYLAMIDE; ACRYLIC acid; COLLOIDS; DRUG delivery systems; MATHEMATICAL models; SIMULATION methods &; models
- Publication
Canadian Journal of Chemical Engineering, 2011, Vol 89, Issue 6, p1521
- ISSN
0008-4034
- Publication type
Article
- DOI
10.1002/cjce.20634