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- Title
Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication.
- Authors
ANDO, T.; MINAMI, M.; ISHIGURO, K.; MAEDA, O.; WATANABE, O.; MIZUNO, T.; FUJITA, T.; TAKAHASHI, H.; NOSHIRO, M.; GOTO, H.
- Abstract
Background Recent evidence suggests that Helicobacter pylori infection is involved in the pathogenesis of extra-gastrointestinal diseases such as coronary heart disease. Aim To determine the association of H. pylori infection with biochemical parameters of atherosclerosis in the serum. Methods One hundred and fifty-nine patients with H. pylori-positive peptic ulcer (duodenal ulcer, n=89; gastric ulcer, n=70) receiving triple therapy were studied prospectively for up to 3 years for clinical parameters associated with inflammation and cardiovascular events. Blood was tested at the time of annual check-up. Results Eradication was successful in 137 patients (86%), and body weight, body mass index (BMI) and TG levels increased gradually each year. No significant hanges were seen in plasma levels of total cholesterol, interleukin-6 or interleukin-8, whereas those of HDL-C increased significantly, and those of C-reactive protein, fibrinogen and LDL-C decreased. Conclusion There is evidence for the possible implication of H. pylori infection in the etiology of cardiovascular events via its exacerbation of or influence on risk factors of atherogenesis.
- Subjects
HELICOBACTER pylori infections; CORONARY disease; HEART diseases; ATHEROSCLEROSIS; SERUM; PEPTIC ulcer; DUODENAL ulcers; BODY weight
- Publication
Alimentary Pharmacology & Therapeutics, 2006, p58
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2006.00026.x