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- Title
Effect of dual-task interference on the hand fexibility of patients with Parkinson's disease carrying the leucine-rich repeat kinase 2 gene mutation.
- Authors
GUANGAN ZHOU; SHEN YANG; TUANZHI CHEN; PIU CHAN; YIFENG DU
- Abstract
The aim of the present study was to observe the changes in hand fexibility of patients with Parkinson's disease (PD) and the effect of dual-task interference. Patients with PD were distributed into two subgroups: the leucine-rich repeat kinase 2 (LRRK2) mutation PD (LRRK2+) and the LRRK2 mutation-free (LRRK2-) PD groups. The healthy controls were distributed into two subgroups: the LRRK2+ control and the LRRK2- control groups. The frst task was the Purdue pegboard test. The second task was to perform serial seven subtractions. Single-task and dual-task tests were performed, respectively. The numbers of pegs inserted with the dominant hand, non-dominant hand and both hands in the pegboard test and the number of correct responses in the serial seven subtractions test within 30 sec were recorded. The United Parkinson's Disease Rating Scale (UPDRS) III score of examinees in the LRRK2+ PD group was signifcantly higher than that of examinees in the LRRK2- PD group (P<0.05). The number of pegs inserted within 30 sec by patients with PD was significantly lower than that by the controls (P<0.05). The indicators of patients with PD, including number of variation in the subtraction test score when the dominant-hand was used in the pegboard test (NVD), number of variation in the subtraction test score when the non-dominant hand was used in the pegboard test (NVND) and number of variation in the subtraction test score when the both-hand was used in the pegboard test (NVB), were significantly different compared with those of the control group (P<0.05). The difference in the number of correct responses within 30 sec of patients with PD was significantly correlated with the UPDRSIII score (P<0.05). In conclusion, the hand fexibility of patients with PD was markedly lower than that of the controls. When both tasks were performed, the ability markedly decreased in the second cognitive task, particularly in the LRRK2+ PD group.
- Subjects
FUNCTIONAL assessment of Parkinson's disease patients; FLEXIBILITY testing (Physiology); PARKINSON'S disease &; genetics; DARDARIN; KINASES; PHYSIOLOGICAL effects of leucine; BRANCHED chain amino acids; EXTRAPYRAMIDAL disorders
- Publication
Experimental & Therapeutic Medicine, 2013, Vol 6, Issue 6, p1469
- ISSN
1792-0981
- Publication type
Article
- DOI
10.3892/etm.2013.1352