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- Title
Elementary immunology: Na as a regulator of immunity.
- Authors
Schatz, Valentin; Neubert, Patrick; Schröder, Agnes; Binger, Katrina; Gebhard, Matthias; Müller, Dominik; Luft, Friedrich; Titze, Jens; Jantsch, Jonathan
- Abstract
The skin can serve as an interstitial Na reservoir. Local tissue Na accumulation increases with age, inflammation and infection. This increased local Na availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na levels bears broad therapeutic potential: increasing local Na availability may help in treating infections, while lowering tissue Na levels may be used to treat, for example, autoimmune and cardiovascular diseases.
- Subjects
SODIUM metabolism; BIOLOGICAL models; ELECTROLYTES; IMMUNITY; INFECTION; INFLAMMATION; INFLAMMATORY mediators; MACROPHAGES; PHAGOCYTES; PHOSPHORYLATION; SALT; SKIN; T cells; RENIN-angiotensin system
- Publication
Pediatric Nephrology, 2017, Vol 32, Issue 2, p201
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-016-3349-x