We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The renin-angiotensin-aldosterone system in 2011: role in hypertension and chronic kidney disease.
- Authors
Simões e Silva, Ana; Flynn, Joseph
- Abstract
Over the past two decades, considerable advances have been made in our understanding of the renin-angiotensin-aldosterone system (RAAS) and its roles in various disease states. In this review, we will discuss the current state of knowledge of the many components of the RAAS, including new data on prorenin and its receptors, and important angiotensin fragments. The roles of these components of the RAAS in the pathogenesis of primary hypertension and the progression of chronic kidney disease (CKD) will also be highlighted. Given the new understanding of the many components and roles of the RAAS, it may be possible to develop improved therapies for hypertension and CKD.
- Subjects
ANGIOTENSINS; ANGIOTENSIN converting enzyme; CELL receptors; CHRONIC kidney failure; HYPERTENSION; RENIN; RENIN-angiotensin system; DISEASE progression
- Publication
Pediatric Nephrology, 2012, Vol 27, Issue 10, p1835
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-011-2002-y