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- Title
Reproducibility of the chamber scarification test.
- Authors
Andersen, Klaus Ejner
- Abstract
The chamber scarification test is a predictive human skin irritation test developed to rank the irritation potential of products and ingredients meant for repeated use on normal and diseased skin. 12 products or ingredients can be tested simultaneously on the forearm skin of each volunteer. The test combines with the procedure scratching of the skin at each test site and subsequent closed patch tests with the products, repeated daily for 3 days. The test is pert armed on groups of human volunteers: a skin irritant substance or products is included in each test as a positive control, and a compound with low irritant potential as a negative control, to obtain relative characterization of the irritant potential of the unknown products. The outcome of tests with a positive and negative control product used repeatedly in 13 chamber scarification tests over a 7-year period is reported, and shows high reproducibility of the test. Further, intra-individual variation in skin reaction to the 2 control products in 26 volunteers, who participated 2 × is shown. which supports the conclusion that the chamber scarification test is a useful short-term human skin irritation test with high reproducibility.
- Subjects
CONTACT dermatitis; SCARIFICATION (Body marking); SKIN tests; SKIN inflammation; VOLUNTEERS
- Publication
Contact Dermatitis (01051873), 1996, Vol 34, Issue 3, p181
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/j.1600-0536.1996.tb02170.x