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- Title
Cost-Effectiveness Analysis of Lopinavir/Ritonavir Monotherapy Versus Standard Combination Antiretroviral Therapy in HIV-1 Infected Patients with Viral Suppression in France (ANRS 140 DREAM).
- Authors
Garay, Osvaldo Ulises; Nishimwe, Marie Libérée; Bousmah, Marwân-al-Qays; Janah, Asmaa; Girard, Pierre-Marie; Chêne, Geneviève; Moinot, Laetitia; Sagaon-Teyssier, Luis; Meynard, Jean-Luc; Spire, Bruno; Boyer, Sylvie
- Abstract
Background: Protease inhibitor monotherapy is a simplified treatment strategy for virally suppressed HIV-positive patients that has the potential for cost savings, as fewer drugs are used than with combination therapy. However, evidence for its economic value is limited. Objectives: We assessed the cost-effectiveness of lopinavir/ritonavir monotherapy followed by treatment intensification in case of viral load rebound versus combination antiretroviral therapy (cART) with efavirenz/emtricitabine/tenofovir in HIV-1 infected patients with viral suppression in the ANRS 140 DREAM trial. Methods: DREAM was conducted in 36 French Hospitals between 2009 and 2013. For each treatment strategy, we estimated the unadjusted and multivariate-adjusted mean costs (in €, year 2010 values) and quality-adjusted life-years (QALYs) per patient, as well as incremental costs and QALYs per patient. We then assessed uncertainty using the cost-effectiveness acceptability curve, scenario analyses and cost-effectiveness price-threshold (CEPT) analysis. Results: In the base-case analysis considering 2009–2013 antiretroviral drug (ARV) prices, adjusted incremental costs and QALYs were − €3296 (95% confidence interval [CI] − 5202 to − 1391) and 0.006 (95% CI − 0.021 to 0.033), respectively, over 2 years, suggesting that monotherapy was cost-effective with a probability of 100% at various cost-effectiveness thresholds. In scenario analyses considering 2018 ARV prices, monotherapy remained cost-effective but with a lower probability (94% vs. 100% in the base-case analysis). The current price of cART would have to decrease by 34% to be cost-effective with a probability of 95%. Conclusion: Monotherapy appears to be cost-effective compared with cART for virologically suppressed HIV-positive patients in France. CEPT analysis is a useful tool to identify the preferred strategy to adopt given that ARV prices change rapidly. Trial registration: Clinicaltrials.gov identifier: NCT00946595.
- Subjects
FRANCE; ANTIRETROVIRAL agents; COST effectiveness; RITONAVIR; DIRECT costing; VIRAL load
- Publication
PharmacoEconomics, 2019, Vol 37, Issue 12, p505
- ISSN
1170-7690
- Publication type
Article
- DOI
10.1007/s41669-019-0130-7