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- Title
Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon.
- Authors
Sintasath, David M.; Wolfe, Nathan D.; LeBreton, Matthew; Hongwei Jia; Garcia, Albert D.; Diffo, Joseph Le Doux; Tamoufe, Ubald; Carr, Jean K.; Folks, Thomas M.; Mpoudi-Ngole, Eitel; Burke, Donald S.; Heneine, Walid; Switzer, William M.
- Abstract
Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lymphotropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV-seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter-collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations.
- Subjects
CAMEROON; RETROVIRUSES; T cells; PHYLOGENY; MONKEYS; CERCOPITHECUS; DNA
- Publication
Emerging Infectious Diseases, 2009, Vol 15, Issue 2, p175
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1502.080584